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Open access Aug 2026

A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries

Proteomics holds great promise for identifying potentially druggable effectors of common diseases, yet its application at population-scale across diverse ancestries, remains challenging. Here, we developed genetic imputation models for 2,594 plasma proteins using proteomic and genetic data from 54,219 UK Biobank partic...

Yu Xu, Douglas P. Loesch, H. Taylor et al. · 0 citations
Open access Aug 2026

Liver fat accumulation contributes to discordant genetic risk between coronary artery disease and type 2 diabetes

Background. Type 2 diabetes (T2D) and coronary artery disease (CAD) frequently co-occur, yet the biological pathways that jointly determine risk remain incompletely understood. Most genetic studies have examined shared risk from a single-disease perspective, limiting insight into the mechanisms that generate discordant...

X. Jiang, N. Hirschmüller, H. Taylor et al. · 0 citations

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