BACKGROUND
Kidney failure affects approximately 800,000 adults in the United States, and African Americans carry a disproportionate burden of disease. Robust algorithms for clinical risk prediction, such as the Kidney Failure Risk Equation (KFRE), have previously been validated, whereas the clinical utility of polygeni...
Alana C. Jones, Atlas Khan, Amit Patki et al.· American Society of Nephrolo...· 0 citations
Background and Objectives Stroke and dementia are leading causes of death and disability worldwide, requiring enhanced preventive strategies. Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely used for type 2 diabetes (T2D) and obesity, have demonstrated pleiotropic effects, including cardiovascular benefits,...
Ilana Caro-Châtelier, M. Sargurupremraj, Cheng-Ran Yang et al.· Neurology: Genetics· 1 citation
Functional annotation-informed PRSs and expanded reference panels modestly improved prediction, particularly among EA participants, and limited performance among AA participants underscores the need for larger, more diverse genomic datasets and integrative models incorporating genetic, clinical, lifestyle, and social d...
N. Armstrong, V. Srinivasasainagendra, Amit Patki et al.· Frontiers in Bioinformatics· 0 citations
