Investigating the role of a non-synonymous mutation at dhfr codon 50 in maintaining sulphadoxine-pyrimethamine resistance in Plasmodium falciparum: a modelling study.
BACKGROUND Resistance to antimalarials in Plasmodium falciparum leads to suboptimal treatment outcomes, leading to prolonged illness, complications, and increased mortality. Such resistance arises from mutations that increase parasite survival under drug pressure but typically reduce parasite growth because of metaboli...