Author

H. Walczak

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Sep 2026

FasL-mediated death of activated intratumoral T cells drives secondary resistance to cancer immunotherapy.

Cancer progression following an initial response to immunotherapy (secondary resistance; 2°R) is a major and poorly understood problem. We treated mice bearing B16 melanoma with a combination of a regulatory T cell (Treg) depleting, non-IL-2 blocking antibody (anti-CD25NIB) and an autologous cancer cell vaccine (GVAX)....

Chen Qing, E. Ghorani, K. Foster et al. · Cancer immunology research · 0 citations

Open access Sep 2026

HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death.

TNF can activate both prosurvival and prodeath signaling downstream of tumor necrosis factor receptor 1 (TNFR1). Survival signaling originates from TNFR1-containing membrane-bound complex I, while death signaling is driven by cytosolic complex II. Receptor-interacting protein kinase 1 (RIPK1) is a central component of...

Hao-Hao Lu, Tong-De Du, Lin Li et al. · Nature Structural & Molecula... · 0 citations