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Author

H. Yassine

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Review Open access Sep 2026

Seroprevalence of HSV-1 and HSV-2 in the urban population of Qatar: a population-based study.

OBJECTIVES Epidemiological data on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections remain limited in the Middle East and North Africa. This study estimated HSV-1 and HSV-2 seroprevalence in the urban population of Qatar and examined associations with demographic characteristics. METHODS A retrospect...

Gheyath K Nasrallah, F. Issa, P. Nizamuddin et al. · 0 citations
Open access Sep 2026

Two Versus One COVID-19 Vaccine Dose After Prior SARS-CoV-2 Infection: A Nationwide Retrospective Cohort Study

Abstract Background Immune protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varies by prior infection and vaccination history. This study evaluated whether 2 coronavirus disease (COVID-19) vaccine doses after prior infection provide additional protection compared with a single dose. Metho...

H. Chemaitelly, H. Ayoub, Peter V. Coyle et al. · 0 citations
Open access Aug 2026

Evaluating COVID-19 vaccine effectiveness across epidemiologic designs: test-negative case-control versus retrospective cohort analyses in a nationwide study

Abstract Background Observational studies are central to assessing vaccine effectiveness and informing public health policy. The two most common designs are test-negative case-control and cohort studies, yet direct comparisons of their performance using the same population, data sources, and analytic strategies remain...

Layan Sukik, Pradipta Paul, H. Ayoub et al. · 0 citations
Open access Sep 2026

Mechanistic inhibition of herpes simplex virus-1 UL21 immune-evasion function by natural-product scaffolds: A multi-tier docking, dynamics, and energetic profiling approach

These findings identify natural-product scaffolds with high potential to modulate UL21-mediated immune suppression, with kaempferol 3,7,4′-tri-O-β-glucoside emerging as the most promising candidate and provide a foundation for experimental validation and future antiviral drug development targeting HSV-1.

Muhammad Suleman, Imtiaz Ali, A. M. Sayaf et al. · 0 citations
Open access Jul 2026

Healthy vaccinee effect did not bias COVID-19 vaccine effectiveness estimates

It is shown that vaccine effectiveness against infection and severe, critical, or fatal COVID-19 remained consistent across matching strategies, despite differences in non-COVID-19 mortality, highlighting the importance of using specific outcomes in vaccine effectiveness studies.

H. Chemaitelly, H. Ayoub, Peter V. Coyle et al. · 0 citations
Open access Aug 2026

Genetic Determinants of Infectious Diseases in the Qatari Population

The distribution of infection-related host genetic variants in Qatar is explored and substantial differences in pathogen-associated host variants in a diverse Qatari cohort are revealed, highlighting the need for follow-up validation and future GWAS discovery efforts.

M. Smatti, Y. Al-Sarraj, O. Albagha et al. · 0 citations

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