Author

H. Yim

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Review Jul 2026

Advancing siRNA Therapeutics with Pharmacometrics: A Review of Modeling Approaches and Clinical Applications.

This review examines how model-informed drug development, particularly pharmacometric modeling, has emerged as an essential tool in the advancement of siRNA therapeutics and how quantitative pharmacology addresses developmental challenges, including first-in-human dose selection, optimal dosing intervals, organ impairment effects, and interindividual variability.

Jueun Kang, H. Yim, H. Jeong et al. · Current Gene Therapy · 0 citations