Ferroptosis, an iron-dependent form of regulated cell death, is controlled by cellular metabolism. Nutrients and metabolites determine cell states that render cells sensitive or resistant to ferroptosis. Nuclear receptors can act as cellular sensors for distinct metabolites and nutrients to regulate ferroptosis. We per...
Andrea Kolak, Juliane Tschuck, Shi-Bo Sun et al.· bioRxiv· 0 citations
Pathological platelet activation drives thrombosis and is a major contributor to morbidity and mortality. Current antiplatelet therapies reduce thrombotic risk but target a limited range of signaling pathways, have minimal impact on established platelet aggregates, and are frequently associated with bleeding complicati...
Jan Yağız Buchholz, Maria Shoykhet, Anthea C. Darius et al.· Frontiers in Immunology· 0 citations
This data indicates that modulation of autophagy operates as a protective mechanism in Wilson’s disease and leads to the hypothesis that modulation of autophagy leads to down-regulation of proapoptotic factors.
K. Sarin, Michael L. Schilsky, A. Ala et al.· Hepatology International· 0 citations
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