Author

Hagen U. Tilgner

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Open access Sep 2026

Spatial isoform sequencing at single-cell resolution reveals cell-type-specific spatial isoform variability in multiple brain cell types

Spatial long-read technologies are increasingly common but usually lack single-cell resolution. This leaves unanswered whether spatially variable isoforms reflect variability within one cell type or differences in region-specific cell-type composition. Here, we developed Spl-ISO-Seq2 (500-nm resolution) and accompanyin...

Lieke Michielsen, Andrey D. Prjibelski, Careen Foord et al. · Nature Methods · 1 citation