Hager El Kersh

Ablation of CDK6 and STAT5B rewires T cell developmental dynamics and prevents ALK+ lymphoma formation

CDK6 and STAT5B are well-established oncogenic drivers, but their interplay during transformation remains poorly understood. Here, we demonstrate that simultaneous genetic deletion of Cdk6 and Stat5b in an NPM-ALKTg/+ mouse model completely prevents tumor formation. Immature DN2/3 thymocytes are identified as the cellu...