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Open access Sep 2026

Trends in years lived with disability (YLD) rates of human brucellosis in Xinjiang, China, 2016–2025: a joinpoint regression analysis by sex, age, and region

Brucellosis, a major zoonotic disease highly endemic in Xinjiang, China, causes chronic, disabling infections that drive significant health impairment and disease burden. This study analyzed the long-term trend of the years lived with disability (YLD) rate attributable to human brucellosis in Xinjiang from 2016 t...

Samira Ababakri, Hai-Bo He, Xue-Hui Cao et al. · 0 citations
Open access Jul 2026

Brucella effector protein BspJ inhibits the NF-κB signaling pathway by targeting the Zfp740 promoter region to promote bacterial survival within macrophages

This study systematically elucidates a novel regulatory axis, BspJ-Zfp740-P65/NF-κB, and reveals a new mechanism by which Brucella directly interferes with host transcriptional programs through a nucleus-targeting effector protein to suppress inflammation and establish persistent infection.

Wen-Jia Wang, Xiaoxiao Cheng, Qianyi Zhang et al. · 0 citations

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