Author

Hai-Bo Jia

3 papers indexed here

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Sep 2026

Inhibition of Programmed Cell Death-1 in Cytotoxic CD8+ T Cells Exacerbates Pressure Overload-Induced Cardiac Injury.

BACKGROUND The use of anti-programmed cell death-1 (PD-1) antibody increases heart failure (HF) risk in patients with cancer with preexisting cardiovascular conditions. However, the underlying mechanism remains incompletely understood. METHODS To evaluate the effects of anti-PD-1 antibody on transverse aortic constri...

Ming-Ming Wu, Yu Sun, Yue Zhang et al. · Circulation · 0 citations

Review Oct 2026

Cell-death-driven plaque evolution: macrophage fate and opportunities for targeted therapy.

This review explores how macrophages derived from hemogenic endothelial cells and bone marrow contribute to disease development, functioning either as tissue-resident cells or via systemic circulation, by delineating the macrophage life cycle from origin to distinct cellular fates within the plaque environment.

Si-Hang Zhang, Yue-Hong Wang, B. Yi et al. · International Immunopharmaco... · 0 citations

Open access Sep 2026

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

ABSTRACT Smoking acts as a critical risk factor for atherosclerosis (AS), but the precise molecular mechanisms remain unclear. We performed in vivo experiments with TAR‐injected ApoE−/− mice and in vitro co‐culture of macrophages with extracellular vesicles (EVs) from TAR‐treated endothelial cells (ECs). Single‐cell RN...

Xin-Xin Zhu, Yu-Wu Chen, Wei Meng et al. · Advancement of science · 0 citations