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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Hai-Fen Tian

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Review Open access Oct 2026

NEDD4-1: from molecular mechanisms to clinical translation in human diseases

Neural precursor cell expressed developmentally downregulated protein 4-1 (NEDD4-1), the founding member of the HECT family of E3 ubiquitin ligases, mediates substrate protein ubiquitination through its C2, WW, and HECT domains. It plays a key role in protein degradation via both the ubiquitin-proteasome system (UPS) a...

Hai-Fen Tian, Yong-Sheng Huang, Yun Liang et al. · 0 citations

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