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Hai-Guo Yu

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Review Open access Sep 2026

Biological roles and clinical translation of low-density neutrophils in rheumatic, autoimmune and inflammatory diseases: paradigm reconstruction and unresolved questions

Neutrophils are increasingly recognized as a heterogeneous lineage rather than a uniform population of short-lived innate effector cells. Low-density neutrophils (LDNs; often termed low-density granulocytes, LDGs) are operationally defined by their co-sedimentation with peripheral blood mononuclear cells after density-...

Zhi-Dan Fan, Wen-Jing Zhu, Pan-Pan Wang et al. · 0 citations

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