The clinical efficacy of vincristine (VIN) is often restricted by dose-limiting toxicity, poor tumor selectivity, and rapid systemic distribution. Another biomolecule, thymoquinone (TQ), has negligible toxicity, but poor aqueous solubility and limited bioavailability hamper its use in cancer therapy. In this study, a f...
S. Khan, Muhammad Rafiq, A. Raouf et al.· Colloids and Surfaces B: Bio...· 0 citations
Abstract Effective drug delivery to the central nervous system remains a persistent challenge owing to the blood–brain barrier (BBB), heterogeneous pathological microenvironments, and the limited capacity of conventional carriers to achieve precise spatiotemporal control over drug release. Multifunctional hybrid nanome...
Yu-Qin Wu, Mu-Kun Wang, Tian-Peng Li et al.· International Journal of Nan...· 0 citations
Current hemostatic materials often face challenges associated with delayed action and insufficient stability on wet bleeding surfaces. Here, we designed and screened three short self-assembling peptides by integrating amphiphilic motifs, β-sheet-associated assembly, and intrinsic antioxidant properties. Through systema...
Ya-Nan Li, Kai Xiang, Jun Ma et al.· Biomaterials Advances· 0 citations
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