Acetylation–ubiquitination crosstalk in NLRP3–gasdermin pyroptosis: a substrate-state framework with relevance to ulcerative colitis
Acetylation and ubiquitination regulate inflammatory cell death, but evidence that they act together in ulcerative colitis (UC) remains limited. This review examines their interactions in nucleotide-binding oligomerisation domain-, leucine-rich repeat- and pyrin domain-containing protein 3 (NLRP3) and gasdermin D (GSDM...