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Author

Hai-Ming Jin

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Open access Aug 2026

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption.

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapies that selectively inhibit resorptive f...

Yihe Li, Qi-Hang Wu, Shengnan Qin et al. · 0 citations
Sep 2026

Trans-zeatin suppresses osteoclastogenesis and prevents estrogen deficiency-induced bone loss by modulating Nrf2-mediated redox homeostasis and AKT signaling.

Postmenopausal osteoporosis (PMOP) is a metabolic bone disorder driven by excessive osteoclast (OC) activity, but current therapies are limited by adverse effects. Trans-zeatin (TZ), a naturally occurring plant cytokinin with antioxidant properties, has not been investigated in bone metabolism. Here, we show that TZ su...

Yong Xiao, Qi-Chen Lu, Miao-Miao Shi et al. · 0 citations

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