Author

Hai-Song Liu

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Review Open access Sep 2026

Stem cell strategies for cell replacement therapy in endocrine diseases

Conventional therapies for endocrine hormone deficiencies, including hormone replacement therapy and solid organ transplantation, are hampered by the lack of physiological regulation or donor shortage, respectively. Directed differentiation of human pluripotent stem cells has opened new avenues for cell replacement the...

Chen Mi, Xie Cheng, Jing-Yan Tang et al. · Cell Transplantation · 0 citations

Open access Aug 2026

Stage-specific signaling modulation generates low-tumorigenicity thyroid progenitors from human pluripotent stem cells

Introduction Human pluripotent stem cell (hPSC)-derived thyroid cells hold great promise for thyroid disease modeling, drug screening, and cell replacement therapies. However, the direct differentiation of hPSCs into functional thyroid follicles remains challenging, suggesting deficient specification of hPSC-derived pr...

Li-Li Dong, Man-Zhen Peng, Chuan-Yu Yao et al. · Frontiers in Endocrinology · 0 citations