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Hai-Xing Xu

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Open access Aug 2026

Proximity-induced protein deglycosylation by endogenous O-GlcNAcase

O-GlcNAcylation is an important post-translational modification that regulates numerous cellular processes, yet tools enabling selective removal of O-GlcNAc from individual proteins via endogenous O-GlcNAcase (OGA) in living cells remain limited. Here, we report De-O-GlcNAcylation-targeting chimeras (DOGTACs), a chemic...

Hai-Xing Xu, Bo-Wen Ma, Yun-Peng Huang et al. · 1 citation

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