Recently, inhibiting thioredoxin-interacting protein (TXNIP), a protein that plays critical roles in glucose metabolism, has emerged as a promising therapeutic strategy for diabetes. Through screening a compound library using a TXNIP reporter system, we identified an orally bioavailable small molecule (SKL-1223) that e...
Zhi-Kuan Luo, Jun Han, Tao Zhong et al.· Journal of Medicinal Chemist...· 0 citations
ABSTRACT African swine fever virus (ASFV) is the causative agent of ASF, a highly contagious and frequently fatal hemorrhagic disease in domestic swine and wild boars, posing a significant threat to the global pig industry. To ensure successful replication, ASFV may modulate cellular stress mechanisms to hijack the hos...
Shuai Fan, Han Zhong, Dan Li et al.· Journal of Virology· 0 citations
ABSTRACT Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging bat-derived coronavirus, causes severe diarrhea and mortality in young hosts and exhibits cross-species transmission potential. However, no licensed vaccines are currently available. In this study, we constructed a recombinant pseudorabies virus...
Yu Zhang, Yue-Yue Duan, Lei Shi et al.· Journal of Virology· 0 citations
African swine fever virus (ASFV) is a highly pathogenic agent that poses a severe threat to the global swine industry. The biological function of A859L, an ASFV-encoded RNA helicase, remains largely elusive. Here, we show that A859L is highly conserved across diverse ASFV isolates and belongs to the SF2 superfamily of...
This study identifies LY6E as a previously unrecognized host restriction factor for PRV and highlights the role of surface proteins in controling viral entry, which broadens the antiviral spectrum of LY6E to DNA viruses, beyond its previously reported host–viral interaction in RNA viruses.
Tanveer Ali Fazlani, Tian-Xing Cao, Yi-Chao Wang et al.· Veterinary Research· 0 citations
This study identifies a novel DNAJA3-TRIM21-TOLLIP axis that restricts FMDV infection through selective autophagy, establishes TOLLIP as a host restriction factor against picornaviruses, and reveals potential molecular targets for antiviral intervention.
Wei Zhang, Yang Yang, Wenhua Shao et al.· Autophagy· 0 citations
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