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Author

Hai-Yan Jiang

2 papers indexed here

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Review Open access Oct 2026

The Dual Role of Piezo1 in Cancer: Mechanotransduction, Microenvironment Remodelling, and Therapeutic Opportunities

: The mechanosensitive ion channel Piezo1 translates physical cues from the tumor microenvironment—including extracellular matrix stiffness, fluid shear stress, and compressive forces—into intracellular calcium signals and downstream cascades, playing a pivotal role in cancer. Piezo1 exhibits pronounced tumor-type depe...

Hai-Yan Jiang, Ying Liu, Fei Xue et al. · 0 citations
Review Open access Sep 2026

Advances in Drug Delivery Systems for Breast Cancer: From Microenvironment Barriers and Smart Carriers to Clinical Translation Strategies

Abstract Breast cancer heterogeneity and its complex tumor microenvironment (TME) are key drivers of therapeutic failure and multidrug resistance (MDR). Drug delivery systems (DDS) provide an important approach, but their clinical translation remains limited by biological variability, formulation complexity, and manufa...

Gui-Wen Liang, Chu-Lin Zhu, Hua-Lin Sun et al. · 0 citations

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