Discovery of Novel 2-(2-Benzimidazole)-Substituted Tetrahydrofur-ans as Potent and Selective NaV1.8 Inhibitors for the Treatment of Pain
Selective inhibition of voltage-gated sodium channel 1.8 (NaV1.8) is a validated non-opioid analgesic strategy. Guided by the well-documented metabolic features of marketed VX-548 in humans and rats, we conducted rational structural optimization to circumvent its major reported metabolic pathways while preserving tar...