Open access
Sep 2026
GSK3β and Plk1 sequentially phosphorylate ATP–citrate lyase to promote homologous recombination
An AKT-GSK3β-Plk1-ACLY signaling module that links the DDR to nuclear metabolism is defined, revealing a critical mechanism by which kinase signaling facilitates acetyl-CoA–dependent chromatin remodeling to preserve genome integrity.
Shi-Nan Zhou, Xin-Yu Zhou, Qin-Fu Chen et al.
· Science Advances · 0 citations