Open access
Sep 2026
Silver(I)-mediated amide-to-ester transformation on unprotected peptides for protein chemical synthesis and engineering
Chemical protein synthesis has transformed the preparation of homogeneous peptides and proteins with site-specific modifications. Serine/threonine ligation offers a practical route to access difficult peptides and proteins via its aggregation-breaking intermediate, yet the preparation and regeneration of the prerequisi...
Zhen-Quan Sun, Wai-Yin Yau, Hua-Jie Kang et al.
· Science Advances · 0 citations