A key challenge in enzymatic electrocatalysis is the precise control of enzyme orientation on electrode surfaces to enable efficient direct electron transfer. Binding peptides have been reported to be helpful in assisting the favorable orientation of multicopper oxidases, while seeking and engineering natural binding...
An artificial intelligence-guided strategy to simultaneously improve the thermostability, pH tolerance, and catalytic activity of glucoamylase from Penicillium oxalicum (PoGA) and folding energy guided recombination to achieve simultaneous multi property optimization is developed.
Jie Qiao, Xiao-Rui Ma, Yi-Bo Song et al.· bioRxiv· 0 citations
Metal-organic frameworks (MOFs) are widely used for enzyme immobilization due to their tunable pore structures and high stability. However, whether a relatively universal MOF carrier can support diverse enzymatic reactions remains unclear. Herein, we systematically evaluated 120 MOF-enzyme-substrate combinations using...
Xiu-Feng Wang, Bo Zhou, Yu-Han Huang et al.· ACS Applied Materials and In...· 0 citations
How recent advances in machine learning are reshaping AMP research is examined, driving a shift from large-scale discovery toward precision-guided prediction and design and emphasizing integrated generative-predictive pipelines, interpretable models, and closed-loop experimental validation as key enablers for the devel...
