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Author

Hai-Yang Lu

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Sep 2026

ERO1A is a hypoxia-ER bridge in NSCLC: from pan-cancer identification to a dual-reporter visualization system.

A dual-reporter system, ERO1Ap2-miRFP670/5HRE-EGFP, driven by the ERO1A promoter and hypoxia response element (HRE), enables real-time, visual monitoring of the dynamic interplay between ER function and the tumor hypoxic microenvironment by simultaneously tracking ERO1A promoter activity and HIF-1α pathway activation.

Xiao-Yu Yang, Peng Chang, Dao-Yi Quan et al. · 0 citations

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