Open access
Aug 2026
LPA1-Induced EMT of Retinal Pigment Epithelial Cells Promotes Subretinal Fibrosis via USP1-Mediated Deubiquitination and Stabilization of ZEB1
Targeting the LPA1/USP1/ZEB1 axis may provide a promising therapeutic strategy for nAMD-associated SRF by driving RPE EMT through USP1-mediated deubiquitination and stabilization of ZEB1.
Manhui Zhu, Liang Cui, Yang Guo et al.
· Investigative Ophthalmology... · 0 citations