Author

Haissi Cui

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Open access Sep 2026

Cell Surface Sialoglycan Engineering Through Exogenous mRNA

All human cells display a dense matrix of structurally diverse glycans that often terminate in monosaccharides belonging to the sialic acid family of sugars. While these sialoglycans are now recognized as critical regulators of human immunity, there is a lack of technologies that provide precise, transient control over...

Vanessa Affe, Qing-Yu Shi, Olivia Mann-Delany et al. · bioRxiv · 0 citations

Open access Sep 2026

A Metabolic Labeling Strategy for Tracking Protein Synthesis in Complex Biological Systems

Protein synthesis supports most biological processes. In the brain in particular, protein synthesis plays a critical role in physiological and pathological states. Here, we describe Tellurophene-Alkyne Cycloaddition-mediated Amino acid Tagging (TeACAT), a versatile strategy for fast, facile, and flexible tagging of new...

Yong Bu, Samuel P. Nyandwi, F. de Lima Alves et al. · bioRxiv · 0 citations

Aug 2026

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.

This work combined site-specific chemical modification of sup-tRNAs with cargo-tailored pulmonary lipid nanoparticle (LNP) engineering to overcome barriers and restore cystic fibrosis transmembrane conductance regulator (CFTR) expression and function.

Jin-Gan Chen, Mu-Ye Zhou, Song-Tao Dong et al. · Science · 2 citations