Haiyan Zhang

Spatial transcriptomics reveals site-specific cellular and metabolic heterogeneity in bladder carcinoma in situ

Bladder carcinoma in situ (CIS) is a multifocal, non–muscle-invasive disease with a high risk of progression to muscle-invasive cancer. Current management strategies are often guided by genomic profiling of single tumor samples, which incompletely capture tumor heterogeneity and may contribute to treatment failure. In...