Review
Open access
Oct 2026
Differences in Somatic Mutations Between Early-Onset and Late-Onset Colorectal Cancer: A Systematic Review and Meta-Analysis
Background: Early-onset colorectal cancer (EOCRC, diagnosed <50 years) is increasing globally and presents with advanced clinicopathological features, yet its mutational landscape compared to late-onset CRC (LOCRC) remains poorly defined. Methods: We systematically searched PubMed and Embase (January 2016–December 2025...
Hui Lionel Raphael Chen, Jun Yan Ian Wee, Jun Kiat Thaddaeus Tan et al.
· Cancers · 0 citations