Open access
Sep 2026
FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape
ABSTRACT Antigen‐loss variants (ALVs) are a major cause of relapse following chimeric antigen receptor (CAR) T cell therapy, particularly in solid tumors where antigen heterogeneity and immune suppression prevail. By integrating public single‐cell RNA sequencing analysis with experimental validation, we identify the tr...
Yi-Han Zhu, Xing-Wei Xie, Xiao-Hua Wu et al.
· Advancement of science · 0 citations