Han-Jun Jiang

Cdk1 heterozygosity triggers premeiotic endoreplication and unreduced sperm formation via the Cdk2/Ccne1-Fzr1a pathway in loach, a teleost.

Polyploidy represents a major driver of eukaryotic genome evolution. In vertebrates, premeiotic endoreplication is considered as an important route to polyploidization, yet the molecular basis governing this process remains elusive. Here, we reported that heterozygous mutation of cdk1 in the loach, Misgurnus anguillica...