Open access
Sep 2026
De novo design of functional RNAs through higher-order interactions
Designing RNA sequences that reliably adopt functional three-dimensional structures remains a central challenge in RNA engineering because folding depends on cooperative interactions beyond canonical base pairing. Here we present DS3dRNA, an interaction-based framework for de novo RNA sequence design that combines a th...
Tong-Wei Yuan, Dong Wang, Xin-Long Chen et al.
· bioRxiv · 0 citations