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Author

Han-Lin Wu

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Preprint Sep 2026

Direct Conditional Transition Sampling for Diffusion Inverse Problems

Training-free diffusion inverse solvers typically choose between local measurement guidance and costly clean-space posterior updates. Independent posterior refresh can improve global correction by sampling a clean conditional and re-noising it, but its practical realization requires probability-flow ODE integration and...

Qi Yu, Han-Lin Wu, Xiao-Hui Sun · 0 citations
2025

Rationalized All-Atom Protein Design with Unified Multi-Modal Bayesian Flow

This work proposes the first Bayesian flow formulation for protein backbone orientations by recasting orientation modeling as an equivalent hyperspherical generation problem with antipodal symmetry and delivers consistently exceptional performance in both peptide and antibody design tasks.

Han-Lin Wu, Yuxuan Song, Zhe Zhang et al. · 0 citations

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