Open access
Oct 2026
Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR
Mechanosensitive channels are central to cellular responses to membrane tension, yet the structural basis of their gating remains incompletely understood. Here, we determine the structures of wild-type and Gly22→Ser (G22S) mutants of MscL from Escherichia coli (EcMscL) by cryogenic electron microscopy (cryo-EM) in pept...
Tao-Ran Xiao, Alexandra Kovinko, C. Shi et al.
· Science Advances · 0 citations