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Open access Sep 2026

Endothelial Dysfunction and Metabolic Reprogramming in Cardiovascular Diseases

Endothelial cells regulate hemodynamics, inflammation, and vascular barrier integrity, thereby playing a central role in vascular homeostasis. Pathological conditions, including hypertension, hyperglycemia, and hyperlipidemia, induce metabolic reprogramming in these cells, altering the balance among glycolysis, fatty a...

Hong-Yu Chen, Ying-Liang Zhao, Cheng-Xin Ge et al. · 0 citations
Sep 2026

5-Methoxyflavone alleviates high-fat diet-induced atherosclerosis in ApoE-/- mice through modulation of ACADM.

Atherosclerosis (AS) is a chronic vascular pathology and a leading cause of global cardiovascular morbidity and mortality, with dysregulated lipid metabolism acting as a primary driver of its progression. 5-Methoxyflavone (5-MF), a natural flavonoid, exhibits known lipid-modulating and antioxidant properties; however,...

Hao-Yang Zheng, Yi-Qing Zhao, Yu-Fei Huo et al. · 0 citations

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