Han Wen

MEGA-ODE: Learning Biologically Structured and Navigable Continuous Perturbation Dynamics from Sparse Omics

In a COVID-19 patient cohort, predicted intermediate profiles improved retrospective disease-stage stratification relative to observed profiles alone, while expert programs highlighted immune and inflammatory signals associated with severity, and these results support biologically structured continuous-time modeling for prediction, interpretation and virtual-perturbation prioritization from sparse temporal omics data.