Open access
Sep 2026
Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells.
BACKGROUND Intervertebral disc degeneration (IDD) is a primary cause of low back pain, closely associated with the senescence of nucleus pulposus cells (NPCs). Energy metabolism disorders and lactate accumulation are observed in degenerated intervertebral discs. However, the molecular mechanism through which lactate ac...
Wen-Sheng Zhang, Ling Mo, Hai-Wei Guo et al.
· Frontiers in Bioscience · 0 citations