Han-Xiao Lin

Unraveling the regulatory nexus of aggrephagy in ALS: identification of novel candidate biomarkers and molecular triggers

Through S100a6 overexpression and knockdown experiments in an NSC34 motor neuron-like ALS model, it is found that S100a6 impaired autophagy and promoted SOD1 aggregation, further validate its potential as a biomarker and provide new insights into the pathogenesis of ALS.