Author

Han-Yu Chen

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Open access Sep 2026

Allosteric pathways govern Gα protein coupling selectivity at promiscuous GPCRs

It is suggested that Gα protein selectivity is an allosterically encoded property of GPCRs and provide a conceptual framework for designing ligands and receptors with tailored Gα protein-biased signaling.

Tegvir S. Boora, Han-Yu Chen, Aaron Cho et al. · bioRxiv · 0 citations

Open access Aug 2026

Interpretable Machine Learning Model of Receptor Dynamics Reveals AT1R Allostery and a Negative Allosteric Modulator

This work developed an interpretable probabilistic framework that extracts residue-level dependencies from MD ensembles using Bayesian network modeling (BNM) and establishes a generalizable and interpretable framework for uncovering GPCR allosteric communication networks and discovering modulators that exploit these ne...

Han-Yu Chen, Yoon Namkung, Zahra Asadi Jafari et al. · bioRxiv · 0 citations