Author

Han-Yuan Zhao

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Review Open access Oct 2026

Multimodal biomarkers for early detection and immunotherapy assessment in hepatocellular carcinoma: integrating liquid biopsy, AI-based imaging and tumor immune profiling

Hepatocellular carcinoma (HCC) commonly develops in chronically diseased liver and remains challenging because of late detection, heterogeneity, recurrence and limited hepatic reserve. Immune checkpoint inhibitor (ICI)-based combinations improve outcomes in advanced HCC, but durable responses occur in only a subset of...

Yu-Li Zhao, Xiao-Lei Chen, Han-Yuan Zhao · Frontiers in Genetics · 0 citations

Open access Jul 2026

Metabolic-immunoregulatory subtypes reveal prognostic and therapeutic insights in multiple primary lung cancer

This study identified a metabolically distinct malignant epithelial subpopulation enriched in MPLC tumors, characterized by upregulation of amino acid metabolism pathways and active MHC-II-mediated interactions with immunosuppressive CD4+ Treg cells and mast cells.

Yu-Li Zhao, Han-Yuan Zhao, Hui-Sheng Wu et al. · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Metabolic reprogramming and immune evasion interaction in the tumor microenvironment promote tumor progression

Emerging evidence demonstrates that tumor metabolic reprogramming not only supports tumor-cell proliferation but also promotes the establishment of an immunosuppressive tumor microenvironment (TME) by altering nutrient competition and metabolite accumulation. Therefore, metabolic reprogramming and immune evasion should...

Hai-Lun Wang, Han-Yuan Zhao, Xue-Lu Pu et al. · Frontiers in Oncology · 0 citations