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Author

Hang-Kun Yu

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Open access Oct 2026

AKNA serves as a prognostic biomarker and restrains endometrial cancer progression via STING activation and macrophage reprogramming

AKNA, an AT-hook transcription factor, plays a critical role in cancer development. However, its prognostic value and biological function in endometrial cancer (EC) remain unclear. To systematically investigate AKNA in EC, we integrated multi-omics data (The Cancer Genome Atlas (TCGA), Genotype-Tissue Expr...

Yuan Tu, Ling-Ya Xu, Chen-Fan Tian et al. · 0 citations
Open access Sep 2026

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

It is shown that elevated protein lactylation in EC correlates with heightened tumor stemness and unfavorable prognosis, and a metabolic–epigenetic mechanism linking lactate metabolism to m6A‐mediated stemness regulation is uncovered, establishing IGF2BP3‐K280 lactylation as both a therapeutic vulnerability and a preci...

Peng Jiang, Yun-Feng Zheng, Chen-Fan Tian et al. · 0 citations

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