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Aug 2026

Discovery and Biosynthesis of Brasilanes G−L: N -Acetylglucosamine-Decorated Sesquiterpenoids with Anti-Inflammatory Activity

N-Acetylglucosamine (GlcNAc)-decorated natural products represent a structurally unique class of metabolites that possess diverse biological activities. Through the genome mining of Coccidioides sp. CMB-TN39F, we identified a GlcNAc transferase-encoding terpene synthase gene cluster brc. Heterologous expression of th...

Ming-Min Wu, Yao-Hui Shi, Yu-Wei Lin et al. · 0 citations
Aug 2026

Radical Mechanism and Stereochemical Control in Consecutive C-C Bond Formation by the Nonheme Iron Enzyme Hvm1.

Iron(II)/2-oxoglutarate-dependent (Fe/2OG) enzymes catalyze consecutive C-C bond formations to assemble complex heterobicyclic ring systems and generate three new stereocenters in piperazine alkaloids helvamide B and the arizonamides through C(sp3)-H activation─a transformation that remains challenging in synthetic che...

Shengbin Zhou, Jia-Peng Zhang, Jia-Yu Zuo et al. · 0 citations

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