A self-adjuvant trivalent T4 bacteriophage nanoparticle vaccine induces broad protective immunity against Orthoebolaviruses.
Orthoebolaviruses, including Zaire virus, Sudan virus, and Bundibugyo virus, remain major public health threats because of their high case-fatality rates and recurrent outbreaks. Although licensed vaccines provide effective protection against EBOV, broadly protective vaccines against multiple pathogenic orthoebolavirus...