Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization worldwide. Its molecular epidemiology rests on consensus G-gene sequences, which capture only the dominant virus in each infection. Deep sequencing reveals far more variation inside each host. Linking those variants to one another gives a fi...
The long-standing challenge of seasonal influenza vaccines providing poor protection is attributed to the rapid and continuous evolution of the virus. In theory, the recommendation of vaccine strain is to predict the dominant strain with best fitness in the upcoming season. Here, we develop FutureFlu, a biologically-gr...
Lu-Yao Qin, Meng-Yi Zhang, Xiao-Yuan Liu et al.· bioRxiv· 0 citations
The long-range RNA-RNA interaction between the termini of a flavivirus genome is controlled by multiple local RNA secondary and tertiary structures. However, a complete picture of this essential genome cyclization process is still elusive. Herein, by using selective 2′-hydroxyl acylation analyzed by primer extension (S...
Yi-Ge Luo, Jing-Yi Zhang, Dan Li et al.· bioRxiv· 0 citations
This study reports a nosocomial cluster of DBV infections, which occurred through human-to-human transmission, and highlights the value of integrating epidemiological investigation, virus isolation, microneutralization assays, and whole-genome sequencing to establish transmission chain, reconstruct the outbreak, and as...
Shan Hong, Kai Li, Jing-Qi Yang et al.· International Journal of Inf...· 0 citations
