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Open access Aug 2026

Single-cell transcriptomic landscape delineates pathogenic NK cell subpopulations and key mediators in systemic inflammatory response syndrome

Systemic inflammatory response syndrome (SIRS) carries high ICU morbidity, sepsis lacks standardized therapies, and stage-variable natural killer (NK) cell function in SIRS remains poorly defined due to insufficient single-cell evidence. Herein, we analyzed public LPS-induced SIRS peripheral blood single-cell RNA seq...

Hong-Ling Jia, Hang Zhao, Yan Li et al. · 0 citations
Review Open access Aug 2026

Microglial immunometabolism in Alzheimer's disease: A stage-resolved trajectory from adaptive remodeling to the metabolic paradox.

This review introduces the "metabolic paradox" as an operational descriptor: a concurrent, same-cell mismatch between increased substrate uptake or inflammatory activation and declining bioenergetic efficiency and homeostatic function.

Yue Zou, Yi Ou, Hang Zhao et al. · 0 citations

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