Open access
Oct 2026
Aebp1 drives a ceramide-gated Calhm2 calcium influx that injures podocytes in diabetic kidney disease.
INTRODUCTION Podocyte injury is a critical determinant of diabetic kidney disease (DKD) and other proteinuric nephropathies; however, the mechanisms linking lipotoxicity to cytoskeletal disruption remain unclear. OBJECTIVES This study aimed to identify a central regulator linking lipotoxicity to podocyte injury, deci...
Ai-Ping Duan, Yu-Cui Jiang, Xia Wang et al.
· Journal of Advanced Research · 0 citations