Author

Hao Chai

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Review Open access Sep 2026

Transposable Element Dysregulation in Hepatocellular Carcinoma: Epigenetic Mechanisms, Immune Remodeling, and Translational Opportunities.

Hepatocellular carcinoma (HCC) commonly develops in the context of chronic liver injury, viral hepatitis, metabolic dysfunction, alcohol-related liver disease and cirrhosis. Although immune checkpoint inhibitor-based combination therapies have improved the treatment of unresectable HCC, primary and acquired resistance...

Xiao-Peng Chen, Bao-Ding Li, Hao Chai et al. · Journal of Hepatocellular Ca... · 0 citations

Review Open access Jul 2026

Deciphering immunosuppressive niches by spatial single-cell proteomics: spatial interaction networks and translational opportunities

Current research findings on the cellular composition, spatial structure, and regulatory mechanisms of the immunosuppressive microenvironment are summarized and the emerging clinical value of space biomarkers and interaction networks in patient stratification, therapeutic target identification, and precision immunother...

Hao Chai, Lang Wu, Xiaopeng Chen et al. · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Research and advances in TK1-mediated metabolic reprogramming in modulating the tumor immune microenvironment in hepatocellular carcinoma

A conceptual framework is proposed in which TK1 is viewed not merely as a proliferation marker but as a potential regulator of the metabolic–immune ecosystem in HCC, which may facilitate the development of novel biomarkers and precision therapeutic strategies for patients with HCC.

Hao Chai, Lang Wu, Ming-Hao Li · Discover Oncology · 0 citations