Hao Chen

Expression of the Human R163C-RYR1 Gain-of-Function Mutation Modified 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Developmental Neurotoxicity in Weanling Mice

It is demonstrated that PCB 95 caused behavioral deficits coincident with altered patterns of basal and training-induced dendritic arborization and behavioral and dendritic responses to PCB 95 were altered by expression of the human R163C-RYR1 gain-of-function mutation, supporting the involvement of RYR1-dependent mech...