Author

Hao Chen

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Open access Oct 2026

A statistical framework for integrative imaging genomics with biclustering and ensemble penalized regression in Alzheimer's disease.

Imaging genomics provides a powerful paradigm for decoding the complex interplay between molecular variation and brain functional phenotypes in neurodegenerative disorders. In this study, the molecular modality is specifically gene expression data rather than time-invariant genetic variants. However, statistically inte...

Hao Chen, Yong He, L. Hou et al. · NeuroImage · 0 citations

Open access Sep 2026

TL-HDMR: a transfer learning framework for advancing equitable causal inference reveals metabolic signatures of stroke across multiple ancestries

Abstract The limited genetic diversity in genome-wide association studies (GWAS) poses a significant challenge to the generalizability and equity of biomedical discoveries. Most causal inferences, particularly from high-dimensional phenomes (e.g. metabolomics), are primarily based on European populations, and their app...

Lei Hou, Xiao-Hua Zhou, Fu-Zhong Xue et al. · Briefings in Bioinformatics · 0 citations