Open access
Jul 2026
Antidepressant-like effects of ketamine involve CX3CL1/CX3CR1 signaling-mediated synaptic plasticity in the mPFC.
It is demonstrated that CX3CL1/CX3CR1 signaling-mediated synaptic plasticity played essential roles in ketamine's antidepressant-like effects, which opened a new door to targeting chemokines to improve depression symptoms.
Yong-Yu Yin, Si-Rui Sun, Hui-Ying Zhang et al.
· Translational Psychiatry · 0 citations